Metagenics was the first company to market and deliver SPMs as a supplement in North America and this product is the more concentrated and improved formulation of the original. In 2 separate case studies, athletes were supplemented with SPM active and asked to self-report their mood and level of fatigue and pain. Following daily intakes of SPMs for 8 weeks, participants showed the following changes: significant decrease in pain levels immediately and 24 hours after workouts; increase in emotional wellbeing score measured in categories such as depression, tension and confusion; significant decrease in fatigue and stress and bodily discomfort. Additionally, due to their role in immune response mitigation in the resolution phase of stress or injury to tissues and cells, this product is ideal for people with inflammatory diseases or unresolved injuries.

To summarize, previous research has shown SPMs to be beneficial in the following ways: reducing inflammation which can be helpful in inflammatory conditions such as rheumatoid arthritis, asthma, and cardiovascular disease; promoting tissue regeneration and repair by activating stem cells and promoting angiogenesis (formation of new blood vessels); enhancing immune function by promoting bacterial clearance and increasing lymphocyte (type of white blood cell) function.